Super excited to share my first review paper from my postdoc, also my first co-corresponding paper. It has been a true honor to be in the Trained Immunity community and doubly excited about having my review be part of the Focus Issue: Trained Immunity collective at eLife. The editorial team at eLife is simply fantastic and the reviewers were generous, thoughtful and enhanced the write up. Of course, Biorender makes it so easy to generate beautiful graphics for reviews, which is truly appreciated as a scientist and as a reader of scientific literature.
Consequences of trained immunity- host beneficial and maladaptive.
Trained immunity can be advantageous when enhancing host defense and disease outcomes after vaccination, β-glucan therapy, and viral, bacterial, or fungal infections, and even after exposure to select allergens or pollutants. Yet the same innate memory programs may turn maladaptive, exacerbating graft rejection, promoting atherosclerosis, fueling neurodegeneration, and driving autoimmune conditions such as rheumatoid arthritis. In case of cancer, consequences of trained immunity are context-dependent with leading to host-beneficial or host-detrimental outcomes. Image generated using BioRender.com
payal yokota